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Certain antidepressants, like Tofranil, Tipramine, and Norfranil, can help suppress OAB symptoms, but which one your doctor chooses to prescribe will depend on your specific set of symptoms. For instance, the SSRI class of antidepressants work better for stress incontinence than for urge incontinence, although it’s not clear exactly how it helps. Alternatively, tricyclic antidepressants (Tofranil is one of the more common) are known to have anticholinergic side effects, relaxing the bladder muscle and causing the muscles at the bladder neck to contract. These work best for OAB and mixed incontinence.